• Algorithm for predicting valvular heart disease from heart sounds in an unselected cohort 

      Waaler, Per Niklas Benzler; Melbye, Hasse; Schirmer, Henrik; Johnsen, Markus Kreutzer; Dønnem, Tom; Ravn, Johan Fredrik; Andersen, Stian; Davidsen, Anne Herefoss; Aviles Solis, Juan Carlos; Stylidis, Michael; Bongo, Lars Ailo Aslaksen (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-24)
      Objective: This study aims to assess the ability of state-of-the-art machine learning algorithms to detect valvular heart disease (VHD) from digital heart sound recordings in a general population that includes asymptomatic cases and intermediate stages of disease progression.<p> <p>Methods: We trained a recurrent neural network to predict murmurs from heart sound audio using annotated recordings ...
    • Associations between physical activity, left atrial size and incident atrial fibrillation: the Tromsø Study 1994–2016 

      Heitmann, Kim Arne; Løchen, Maja-Lisa; Stylidis, Michael; Hopstock, Laila Arnesdatter; Schirmer, Henrik; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-24)
      Aims: Left atrial (LA) enlargement is an independent risk factor for atrial fibrillation (AF). Interestingly, some athletes have increased risk of AF, which may be linked to LA enlargement; however, little is known about the relationship between LA enlargement and AF risk at moderate-level physical activity (PA). We aimed to explore the associations between PA, LA size and risk of incident ...
    • Automatic measurements of left ventricular volumes and ejection fraction by artificial intelligence reduces time-consumption and inter-observer variability 

      Olaisen, Sindre Hellum; Espeland, Torvald; Smistad, Erik; Hu, Jieyu; Pasdeloup, David Francis Pierre; Østvik, Andreas; Amundsen, Brage H.; Aakhus, Svend; Rösner, Assami; Stylidis, Michael; Holte, Espen; Grenne, Bjørnar Leangen; Løvstakken, Lasse; Dalen, Håvard (Conference object; Konferansebidrag, 2023-06-19)
    • Automatic measurements of left ventricular volumes and ejection fraction by artificial intelligence: clinical validation in real time and large databases 

      Olaisen, Sindre Hellum; Smistad, Erik; Espeland, Torvald; Hu, Jieyu; Pasdeloup, David Francis Pierre; Østvik, Andreas; Aakhus, Svend; Rösner, Assami; Malm, Siri; Stylidis, Michael; Holte, Espen; Grenne, Bjørnar Leangen; Løvstakken, Lasse; Dalen, Håvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-26)
      Aims - Echocardiography is a cornerstone in cardiac imaging, and left ventricular (LV) ejection fraction (EF) is a key parameter for patient management. Recent advances in artificial intelligence (AI) have enabled fully automatic measurements of LV volumes and EF both during scanning and in stored recordings. The aim of this study was to evaluate the impact of implementing AI measurements on acquisition ...
    • Clinical characteristics, echocardiographic indices of heart failure and mortality in a general population. The Tromsø Study 

      Stylidis, Michael (Doctoral thesis; Doktorgradsavhandling, 2020-08-21)
      <p><i>Background - </i>Ageing of the general population, declining incidence of myocardial infarction (MI) and improvements in medical treatment have resulted in an increase in heart failure (HF) prevalence. At the same time, number of studies linked to all-cause mortality and HF, co-existing HF and chronic obstructive pulmonary disease (COPD) are scarce. <p><i>Objective - </i>To study long-term ...
    • Cross-sectional associations between accelerometry-measured physical activity, left atrial size, and indices of left ventricular diastolic dysfunction: The Tromsø Study 

      Heitmann, Kim Arne; Løchen, Maja-Lisa; Hopstock, Laila Arnesdatter; Stylidis, Michael; Welde, Boye; Schirmer, Henrik; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-31)
      Whereas left atrial (LA) enlargement is an independent predictor for adverse cardiovascular events and all-cause mortality, this is regarded a physiological adaption of exercise. Paradoxically, LA size in athletes may overlap the enlargement observed in patients with cardiac pathology. Current knowledge is mainly derived from studies of athletes, and little is known about cardiac adaptations to ...
    • Global myocardial longitudinal strain in a general population—associations with blood pressure and subclinical heart failure: The Tromsø Study 

      Stylidis, Michael; Leon, David A.; Røsner, Assami; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-18)
      The early detection of subclinical myocardial dysfunction can contribute to the treatment and prevention of heart failure (HF). The aim of the study was to (i) describe myocardial global longitudinal strain (GLS) patterns in a large general population sample from Norway and their relation to established cardiovascular disease (CVD) risk factors; (ii) to determine its normal thresholds in healthy ...
    • Know Your Heart: Rationale, design and conduct of a cross-sectional study of cardiovascular structure, function and risk factors in 4500 men and women aged 35-69 years from two Russian cities, 2015-18 

      Cook, Sarah; Malyutina, S; Kudryavtsev, Alexander; Averina, Maria; Bobrova, Natalia; Boytsov, S; Brage, S; Clark, TG; Diez Benavente, S; Eggen, Anne Elise; Hopstock, Laila Arnesdatter; Hughes, A; Johansen, Heidi; Kholmatova, Kamila; Kichigina, A; Kontsevaya, Anna; Kornev, M; Leong, D; Magnus, Per; Mathiesen, Ellisiv B.; McKee, M; Morgan, K; Nilssen, Odd-Ragnar; Plakhov, I; Quint, JK; Rapala, A; Ryabikov, A; Saburova, Lyudmila; Schirmer, Henrik; Shapkina, M; Shiekh, Suhail; Shkolnikov, VM; Stylidis, Michael; Voevoda, Mikhail; Westgate, Kate; Leon, David Adrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-04)
      Russia has one of the highest rates of cardiovascular disease in the world. The International Project on Cardiovascular Disease in Russia (IPCDR) was set up to understand the reasons for this. A substantial component of this study was the Know Your Heart Study devoted to characterising the nature and causes of cardiovascular disease in Russia by conducting large cross-sectional surveys in two Russian ...
    • Left atrial diameter, left ventricle filling indices, and association with all-cause mortality: Results from the population-based Tromsø Study. 

      Stylidis, Michael; Sharashova, Ekaterina; Wilsgaard, Tom; Leon, David A.; Heggelund, Geir; Røsner, Assami; Njølstad, Inger; Løchen, Maja-Lisa; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-28)
      <p><i>Aims</i>: To examine the associations between diastolic dysfunction indices and long‐term risk of all‐cause mortality in adults over 23‐year follow‐up.</p> <p><i>Methods and results</i>: Participants (n = 2734) of the population‐based Tromsø Study of Norway had echocardiography in 1994–1995. Of these 67% were repeated in 2001 and/or 2007–2008. Mortality between 1994 and 2016 was determined ...
    • Longitudinal Associations Between Cumulative Physical Activity and Change in Structure and Function of the Left Side of the Heart: The Tromsø Study 2007–2016 

      Heitmann, Kim Arne; Welde, Boye; Løchen, Maja-Lisa; Stylidis, Michael; Schirmer, Henrik; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-12)
      Background: Current knowledge about the relationship between physical activity (PA) and cardiac remodeling is mainly derived from cross-sectional studies of athletes, and there is a knowledge gap of this association in the general adult and elderly population. Therefore, we aimed to explore the longitudinal association between cumulative PA and change in cardiac structure and function in a general ...
    • Novel approach to artefact detection and the definition of normal ranges of segmental strain and strain-rate values 

      Kornev, Mikhail; Caglayan, Hatice Aklay; Kudryavtsev, Alexander V; Malyutina, Sofia; Ryabikov, Andrew; Stylidis, Michael; Schirmer, Henrik; Rosner, Assami (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-13)
      Aims - Strain artefacts are known to hamper the correct interpretation of segmental strain and strain-rate (S/SR). Defining the normal ranges of myocardial segmental deformation is important in clinical studies and routine echocardiographic practice. In order to define artefact-free normal ranges for segmental longitudinal S/SR parameters, we investigated the extent to which different types of ...
    • NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population 

      Averina, Maria; Stylidis, Michael; Brox, Jan; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-23)
      Aims The aim of this study was to establish age-specific and sex-specific cut-off values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failure (HF) in a general population.<p> <p>Methods and results Altogether, 1936 participants were randomly selected ...
    • Prediction of chronic heart failure and chronic obstructive pulmonary disease in a general population: the Tromsø study 

      Melbye, Hasse; Stylidis, Michael; Aviles Solis, Juan Carlos; Averina, Maria; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-07)
      <i>Aims</i> - Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are main causes of dyspnoea, and echocardiography and spirometry are essential investigations for these diagnoses. Our aim was to determine the prevalence of HF and COPD in a general population, also how the diseases may be identified, and to what extent their clinical characteristics differ.<br><br> <i>Methods and ...
    • Prevalens av og risikofaktorer for selvrapportert hjerteinfarkt og atrieflimmer hos samer og ikke-samer i Tromsøundersøkelsen 

      Einarsson, Sturla Bjørn; Stylidis, Michael; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-27)
      Hjerteinfarkt og atrieflimmer er ledende årsaker til mortalitet og morbiditet globalt (1). Det norske dødsårsaksregisteret viser imidlertid at risiko for å dø av hjerte- og kar- sykdommer er mer enn halvert fra år 2000 til 2016 (2). Mannsverk et al. viste i 2012 at nedgangen i mortalitet av koronarsykdom i Tromsø skyldes en nedgang i insidens (3). Senere ble det vist at 66 % av nedgangen ...